Effects of a typical and an atypical antipsychotic on the disruption of prepulse inhibition caused by corticotropin-releasing factor and by rat strain

Behav Neurosci. 2005 Aug;119(4):1052-60. doi: 10.1037/0735-7044.119.4.1052.


Male Wistar-Kyoto (WKY) and Brown Norway (BN) rats (11-12 weeks, n = 184) received an injection of saline, haloperidol, or clozapine, followed by an intracerebroventricular infusion of saline or corticotropin-releasing factor (CRF). Rats were tested for prepulse inhibition (PPI) of the acoustic startle response. BN rats showed less PPI than WKY rats, and neither antipsychotic alone enhanced PPI. In WKY rats, both haloperidol and clozapine attenuated the CRF-induced decrease in PPI. In CRF-treated BN rats, clozapine-enhanced PPI. A clozapine-induced decrease in startle amplitude was seen in CRF-treated BN rats but not in CRF-treated WKY rats. Although the disruption of PPI caused by exogenous CRF administration can be reversed by acute antipsychotic treatment, baseline PPI is not altered.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acoustic Stimulation / methods
  • Analysis of Variance
  • Animals
  • Antipsychotic Agents / pharmacology*
  • Behavior, Animal / drug effects
  • Clozapine / pharmacology
  • Corticotropin-Releasing Hormone / pharmacology*
  • Dose-Response Relationship, Drug
  • Dose-Response Relationship, Radiation
  • Drug Interactions
  • Haloperidol / pharmacology
  • Hormones / pharmacology*
  • Injections, Intraventricular / methods
  • Male
  • Neural Inhibition / drug effects*
  • Rats
  • Rats, Inbred BN
  • Rats, Inbred WKY
  • Reflex, Startle / drug effects*


  • Antipsychotic Agents
  • Hormones
  • Corticotropin-Releasing Hormone
  • Clozapine
  • Haloperidol