Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model

J Neuroimmunol. 2005 Dec;169(1-2):86-96. doi: 10.1016/j.jneuroim.2005.08.012. Epub 2005 Sep 26.

Abstract

The purpose of this study was to examine the involvement of the transient receptor potential vanilloid receptor 1 (TRPV1) in inflammatory processes observed in murine allergic contact dermatitis (ACD). Oxazolone-induced ACD evoked a significant ear swelling after 24-72 h. It was augmented in TRPV1 knockout mice at all time points and supported by histological analysis and measure of TNF-alpha. However, tissue swelling and cytokine generation was significantly reduced in both neurokinin 1 receptor and calcitonin gene-related peptide (CGRP) knockout mice. A protective involvement of the TRPV1 receptor was identified of contact dermatitis distinct from mechanisms involving the major pro-inflammatory neuropeptides.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Immunologic / toxicity
  • Animals
  • Calcitonin Gene-Related Peptide / deficiency
  • Calcitonin Gene-Related Peptide / physiology
  • Cytokines / metabolism
  • Dermatitis, Allergic Contact / etiology
  • Dermatitis, Allergic Contact / metabolism*
  • Dermatitis, Allergic Contact / prevention & control
  • Disease Models, Animal
  • Diterpenes / administration & dosage
  • Ear Diseases / drug therapy
  • Ear Diseases / etiology
  • Ear Diseases / pathology
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Neutrophils / metabolism
  • Oxazolone / toxicity*
  • Piperidines / administration & dosage
  • Quinuclidines / administration & dosage
  • TRPV Cation Channels / agonists
  • TRPV Cation Channels / antagonists & inhibitors
  • TRPV Cation Channels / deficiency
  • TRPV Cation Channels / physiology*
  • Time Factors

Substances

  • Adjuvants, Immunologic
  • Cytokines
  • Diterpenes
  • Piperidines
  • Quinuclidines
  • TRPV Cation Channels
  • TRPV1 receptor
  • SR 140333
  • Oxazolone
  • resiniferatoxin
  • Calcitonin Gene-Related Peptide