Abstract
The purpose of this study was to examine the involvement of the transient receptor potential vanilloid receptor 1 (TRPV1) in inflammatory processes observed in murine allergic contact dermatitis (ACD). Oxazolone-induced ACD evoked a significant ear swelling after 24-72 h. It was augmented in TRPV1 knockout mice at all time points and supported by histological analysis and measure of TNF-alpha. However, tissue swelling and cytokine generation was significantly reduced in both neurokinin 1 receptor and calcitonin gene-related peptide (CGRP) knockout mice. A protective involvement of the TRPV1 receptor was identified of contact dermatitis distinct from mechanisms involving the major pro-inflammatory neuropeptides.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adjuvants, Immunologic / toxicity
-
Animals
-
Calcitonin Gene-Related Peptide / deficiency
-
Calcitonin Gene-Related Peptide / physiology
-
Cytokines / metabolism
-
Dermatitis, Allergic Contact / etiology
-
Dermatitis, Allergic Contact / metabolism*
-
Dermatitis, Allergic Contact / prevention & control
-
Disease Models, Animal
-
Diterpenes / administration & dosage
-
Ear Diseases / drug therapy
-
Ear Diseases / etiology
-
Ear Diseases / pathology
-
Mice
-
Mice, Inbred BALB C
-
Mice, Inbred C57BL
-
Mice, Knockout
-
Neutrophils / metabolism
-
Oxazolone / toxicity*
-
Piperidines / administration & dosage
-
Quinuclidines / administration & dosage
-
TRPV Cation Channels / agonists
-
TRPV Cation Channels / antagonists & inhibitors
-
TRPV Cation Channels / deficiency
-
TRPV Cation Channels / physiology*
-
Time Factors
Substances
-
Adjuvants, Immunologic
-
Cytokines
-
Diterpenes
-
Piperidines
-
Quinuclidines
-
TRPV Cation Channels
-
TRPV1 receptor
-
SR 140333
-
Oxazolone
-
resiniferatoxin
-
Calcitonin Gene-Related Peptide