Natural history of familial myomas

Eur J Obstet Gynecol Reprod Biol. 2006 Apr 1;125(2):255-8. doi: 10.1016/j.ejogrb.2005.08.020. Epub 2005 Sep 26.


Objective: To study the natural history of myomas in familial cases and to compare the tendencies of myomas between familial and non-familial cases.

Study design: Subjects with familial and non-familial myomas were identified from the hospital records and the reliable details of the myomas were collected.

Results: In the familial cases there are several myomas, four or more. In the non-familial cases, there is usually only one single myoma, which is bigger than in familial cases. In the familial group, the diagnosis and surgery was made earlier. In the familial group, there were more pregnancies and less infertility problems.

Conclusion: There is a significant difference in the natural history of the familial and non-familial cases. In familial cases, subjects have four or more myomas while in non-familial cases the fibroid is single and large.

MeSH terms

  • Adult
  • Aged
  • Case-Control Studies
  • Family Health
  • Female
  • Humans
  • Leiomyoma / genetics*
  • Leiomyoma / pathology
  • Middle Aged
  • Uterine Neoplasms / genetics*
  • Uterine Neoplasms / pathology