The HLA-B7 allele confers susceptibility to breast cancer in Spanish women

Immunol Lett. 2005 Nov 15;101(2):223-5. doi: 10.1016/j.imlet.2005.03.006. Epub 2005 Apr 7.


Background: Several HLA alleles are associated with susceptibility or protection in breast cancer. The particular allele varies depending on the geographical region. A study in a small group of Spanish patients using serological methods found an association with HLA-B7. We undertook a larger study in southern Spain using molecular biology techniques.

Methods: Genotype variants of HLA class I and II were typed by PCR-SSP in 132 breast cancer patients and 382 healthy controls.

Results: The frequency of the HLA-B7 allele was increased in the patients compared to the controls (P=0.0019; 95% confidence interval, 1.337-3.409, relative risk=2.135). Bonferroni correction of the P showed it was still significant (P(c)=0.0285).

Conclusions: These results support previous suggestions that HLA-B7 is associated with the development of breast cancer in our area.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles*
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / pathology
  • Female
  • Genetic Predisposition to Disease / genetics*
  • HLA-B7 Antigen / genetics*
  • Humans
  • Spain


  • HLA-B7 Antigen