Are influences during pregnancy associated with wheezing phenotypes during the first decade of life?

Acta Paediatr. 2005 May;94(5):553-8. doi: 10.1111/j.1651-2227.2005.tb01938.x.


Aim: Recently, attention has focused on possible early life origins for asthma. We sought to identify whether factors present during pregnancy were associated with development of childhood wheezing phenotypes.

Methods: A whole population birth cohort (n=1456) on the Isle of Wight, UK, was followed through to age 10 y. Where possible, information regarding environmental exposures and events during pregnancy was obtained from the maternity records (n=1238). Children were seen at ages 1, 2, 4 and 10 y, and wheezing symptoms were used to define wheezing phenotypes in the first decade (n=1034).

Results: Risk of early-onsetpersistent wheeze (onset in the first 4 y, still present at age 10) was increased by environmental tobacco smoke exposure in pregnancy (OR=2.44; 95% CI: 1.37-4.34) plus maternal asthma (3.57; 1.84-6.94), but reduced by cat ownership (0.30; 0.13-0.62). Early transient wheeze (onset in the first 4 y, but not present at age 10) was increased by environmental tobacco smoke exposure (1.58; 1.02-2.45), male gender (1.68; 1.09-2.60) and low birthweight (3.65; 1.27-10.52). No environmental factors in pregnancy were associated with late-onset persistent wheeze (onset after age 4 y, still present at 10 y).

Conclusion: In addition to genetics, maternal exposures during pregnancy show association with childhood and especially early-life wheezing phenotypes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Domestic
  • Asthma / etiology*
  • Asthma / genetics
  • Child
  • Child, Preschool
  • Environmental Exposure / adverse effects*
  • Female
  • Humans
  • Infant
  • Male
  • Maternal Exposure / adverse effects*
  • Phenotype
  • Pregnancy
  • Prevalence
  • Respiratory Sounds / etiology*
  • Respiratory Sounds / genetics
  • Smoking / adverse effects
  • United Kingdom / epidemiology