A comparison of high and standard blood transfusion volumes in premature infants

Acta Paediatr. 2005 May;94(5):624-5. doi: 10.1111/j.1651-2227.2005.tb01949.x.


We compared high volume (20 ml/kg) with standard volume (15 ml/kg) packed red blood cell (PRBC) transfusions in a randomized trial. Ten high volume babies received a mean of 2.8 transfusions, while 10 standard volume babies received a mean of 3.4 (p=0.58). No adverse events were attributed to the use of the high volume transfusions.

Conclusion: Higher transfusion volumes appear to be well tolerated. The data can be used in the planning of larger controlled trials in VLBW infants.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Blood Transfusion / methods*
  • Hematocrit
  • Humans
  • Infant, Newborn
  • Infant, Premature