MACiE: a database of enzyme reaction mechanisms

Bioinformatics. 2005 Dec 1;21(23):4315-6. doi: 10.1093/bioinformatics/bti693. Epub 2005 Sep 27.


Summary: MACiE (mechanism, annotation and classification in enzymes) is a publicly available web-based database, held in CMLReact (an XML application), that aims to help our understanding of the evolution of enzyme catalytic mechanisms and also to create a classification system which reflects the actual chemical mechanism (catalytic steps) of an enzyme reaction, not only the overall reaction.


Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Computational Biology / methods*
  • Database Management Systems
  • Databases, Factual
  • Databases, Genetic
  • Databases, Protein*
  • Enzymes / chemistry*
  • Gene Expression
  • Information Storage and Retrieval
  • Internet
  • Models, Chemical
  • Models, Statistical
  • Programming Languages
  • Proteins / chemistry
  • Sequence Alignment
  • Sequence Analysis
  • Software


  • Enzymes
  • Proteins