Long-term effect of bone marrow transplantation in adult-onset adrenoleukodystrophy

Eur J Neurol. 2005 Oct;12(10):807-10. doi: 10.1111/j.1468-1331.2005.01055.x.


We report a long-term outcome of motor function in a patient with adult-onset adrenoleukodystrophy after bone marrow transplantation (BMT). Clinically motor function gradually improved and became almost normal in 2 years after BMT. Serial transcranial magnetic stimulation showed gradual improvement of central motor conduction until 1 year after BMT, and then it became stable. Central motor conduction time and motor threshold were useful for monitoring the central motor function in this patient.

Publication types

  • Case Reports
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenoleukodystrophy / physiopathology
  • Adrenoleukodystrophy / surgery*
  • Adult
  • Bone Marrow Transplantation / methods*
  • Electric Stimulation / methods
  • Evoked Potentials, Motor / physiology
  • Humans
  • Male
  • Time Factors
  • Time*