White-matter changes on MRI as surrogate marker

Int Psychogeriatr. 2003;15 Suppl 1:261-5. doi: 10.1017/S104161020300930X.


This article reviews the use of white-matter changes as identified on MRI as a surrogate marker in clinical trials on vascular dementia. As of yet, insufficient evidence is present to implement rating or volumetric assessment of the burden of white-matter changes as surrogate marker in such trials, in view of the limited sensitivity to change of current methods and the high measurement error.

MeSH terms

  • Aged
  • Biomarkers
  • Brain / blood supply*
  • Brain / pathology*
  • Brain / physiopathology
  • Cerebrovascular Circulation / physiology
  • Dementia, Vascular / pathology*
  • Dementia, Vascular / physiopathology
  • Disease Progression
  • Humans
  • Magnetic Resonance Imaging*
  • Sensitivity and Specificity


  • Biomarkers