Controlled microfluidic interfaces

Nature. 2005 Sep 29;437(7059):648-55. doi: 10.1038/nature04163.


The microfabrication technologies of the semiconductor industry have made it possible to integrate increasingly complex electronic and mechanical functions, providing us with ever smaller, cheaper and smarter sensors and devices. These technologies have also spawned microfluidics systems for containing and controlling fluid at the micrometre scale, where the increasing importance of viscosity and surface tension profoundly affects fluid behaviour. It is this confluence of available microscale engineering and scale-dependence of fluid behaviour that has revolutionized our ability to precisely control fluid/fluid interfaces for use in fields ranging from materials processing and analytical chemistry to biology and medicine.

Publication types

  • Review

MeSH terms

  • Diffusion
  • Microfluidics* / instrumentation
  • Microfluidics* / methods
  • Phase Transition
  • Surface Properties*
  • Surface Tension