A family of putative transcription termination factors shared amongst metazoans and plants

Curr Genet. 2005 Oct;48(4):265-9. doi: 10.1007/s00294-005-0022-5. Epub 2005 Nov 4.


The human mitochondrial transcription termination factor (mTERF) is involved in the regulation of transcription of the mitochondrial genome. Similarity searches and phylogenetic analysis demonstrate that mTERF is a member of large and complex protein family (the MTERF family) shared amongst metazoans and plants. Interestingly, we identify three novel MTERF genes in vertebrates, which all encode proteins with predicted mitochondrial localization. Members of the MTERF family have so far not been detected in fungi, supporting the notion that mitochondrial transcription regulation may have evolved separately in yeast and animal cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Basic-Leucine Zipper Transcription Factors / chemistry
  • Basic-Leucine Zipper Transcription Factors / genetics
  • Conserved Sequence
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / genetics
  • Humans
  • Mammals
  • Mitochondrial Proteins
  • Molecular Sequence Data
  • Phylogeny*
  • Plants / genetics*
  • Sequence Alignment


  • Basic-Leucine Zipper Transcription Factors
  • DNA-Binding Proteins
  • MTERF1 protein, human
  • Mitochondrial Proteins