Prenatal diagnosis of de novo (7;19)(q11.2;q13.3) translocation associated with a thick corpus callosum and Wilms tumor of the kidneys

Prenat Diagn. 2005 Oct;25(10):876-8. doi: 10.1002/pd.1129.


We present a case of prenatal diagnosis of a de novo (7;19)(q11.2;q13.3) translocation associated with ultrasound features, including enlarged cisterna magna, normal vermis, thick corpus callosum, micrognathia, small and low-set ears and right hyperechogenic kidney. Karyotyping was performed at 24 weeks of gestation. Termination of pregnancy was accepted at the parents' request. Postmortem examination confirmed the prenatal findings, but revealed bilateral Wilms tumors of the kidneys. Parental karyotype was normal.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Multiple / genetics
  • Adult
  • Agenesis of Corpus Callosum*
  • Chromosomes, Human, Pair 19 / genetics*
  • Chromosomes, Human, Pair 7 / genetics*
  • Craniofacial Abnormalities / genetics
  • Female
  • Gestational Age
  • Humans
  • Karyotyping
  • Kidney Neoplasms / genetics*
  • Pregnancy
  • Prenatal Diagnosis*
  • Translocation, Genetic / genetics*
  • Wilms Tumor / genetics*