Comparison of "Rose Questionnaire Angina" to exercise thallium scintigraphy: different findings in males and females

J Clin Epidemiol. 1992 Jul;45(7):715-20. doi: 10.1016/0895-4356(92)90048-r.


Validation of the London School of Hygiene (Rose) Questionnaire with objective measures of myocardial ischemia is incomplete. Therefore, we compared the Rose Questionnaire with exercise thallium-201 myocardial scintigraphy in 147 male and 97 female patients with chest pain referred for clinical exercise testing. Of those with "Rose Questionnaire angina", 26% of the females and 73% of the males had positive thallium-201 scans. Negative results on both the Rose Questionnaire and thallium-201 scintigraphy were observed in 71% of the females and 47% of the males. The sensitivity of the Rose Questionnaire was similar in females (41%) and males (44%). The specificity was 77% in males, while in females it was significantly lower at 56%. The specificity values reflect the higher (p less than 0.05) prevalence of "false positive" Rose Questionnaire results in females (75%) compared with males (27%). In addition, males had a greater (p less than 0.05) number of "false negative" results (53%) than females (29%). The accuracy of the Rose Questionnaire for myocardial ischemia was 0.19 in females, 0.48 in males, and 0.29 overall when including both males and females. Our results indicate a generally poor relationship between Rose Questionnaire angina and thallium-201 scintigraphy, an objective measure of myocardial ischemia in patients with chest pain referred to clinical exercise testing. Further, there are gender-specific differences in this relationship between the questionnaire and exercise thallium-201 imaging.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Angina Pectoris / diagnosis*
  • Angina Pectoris / diagnostic imaging
  • Exercise Test*
  • False Negative Reactions
  • False Positive Reactions
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prevalence
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Sex Factors
  • Surveys and Questionnaires*
  • Thallium Radioisotopes
  • Ultrasonography


  • Thallium Radioisotopes