Effect of milk fermented with Lactobacillus acidophilus strain L-92 on symptoms of Japanese cedar pollen allergy: a randomized placebo-controlled trial

Biosci Biotechnol Biochem. 2005 Sep;69(9):1652-60. doi: 10.1271/bbb.69.1652.


A placebo-controlled, single-blind study was conducted to evaluate the effects of Lactobacillus acidophilus strain L-92 (L-92) on the symptoms of Japanese cedar-pollen allergy. This study was carried out during the 2002 and 2003 seasons of Japanese cedar pollination. Twenty-three in-house volunteers were asked to drink 100 ml of heat-treated milk fermented with L-92 containing 5 x 10(10) of the bacteria, twice a day, for 6 consecutive weeks. A similar study was carried out during the 2003 season for 10 weeks, but the daily dose of bacteria was 2 x 10(10). A significant improvement of the ocular symptom-medication score (SMS) was observed in 2002 and of the score of distress of life in 2003. These data show that a daily oral intake of not less than 2 x 10(10) heat-treated L-92 cells improved the symptoms of Japanese cedar pollinosis, thereby contributing to reduce the dose of concomitant medications. However, no blood parameter was significantly affected in these trials.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anti-Allergic Agents / pharmacology
  • Cryptomeria / immunology
  • Cultured Milk Products / immunology
  • Cultured Milk Products / physiology*
  • Female
  • Humans
  • Immunoglobulin E / blood
  • Japan
  • Lactobacillus acidophilus / immunology
  • Lactobacillus acidophilus / physiology*
  • Male
  • Pollen / immunology*
  • Rhinitis, Allergic, Seasonal / blood
  • Rhinitis, Allergic, Seasonal / diet therapy*
  • Rhinitis, Allergic, Seasonal / drug therapy
  • Time Factors


  • Anti-Allergic Agents
  • Immunoglobulin E