On the road to cancer: aneuploidy and the mitotic checkpoint

Nat Rev Cancer. 2005 Oct;5(10):773-85. doi: 10.1038/nrc1714.


Abnormal chromosome content - also known as aneuploidy - is the most common characteristic of human solid tumours. It has therefore been proposed that aneuploidy contributes to, or even drives, tumour development. The mitotic checkpoint guards against chromosome mis-segregation by delaying cell-cycle progression through mitosis until all chromosomes have successfully made spindle-microtubule attachments. Defects in the mitotic checkpoint generate aneuploidy and might facilitate tumorigenesis, but more severe disabling of checkpoint signalling is a possible anticancer strategy.

Publication types

  • Review

MeSH terms

  • Aneuploidy*
  • Chromosomal Instability*
  • Genes, Tumor Suppressor
  • Humans
  • Mitosis* / drug effects
  • Mutation
  • Neoplasms / drug therapy
  • Neoplasms / etiology
  • Neoplasms / genetics*
  • Neoplasms / pathology
  • Signal Transduction