Analysis of a single nucleotide polymorphism in codon 388 of the FGFR4 gene in malignant gliomas

Cancer Lett. 2006 Aug 8;239(2):239-45. doi: 10.1016/j.canlet.2005.08.013. Epub 2005 Sep 29.

Abstract

The FGFR4 codon 388 polymorphism (Arg(388), Arg/Gly(388) or Gly(388)) was determined in glioblastoma multiforme (GBM), anaplastic astrocytomas (AA), diffuse astrocytomas (DA), and control muscles. Arg(388) was rare in AA, GBM, muscles, and was absent in DA. The Arg/Gly(388) and the Gly(388) frequency was equal among GBM and controls. FGFR4 expression was not related to codon 388 in GBM, and no survival differences between Arg/Gly(388) and Gly(388) tumors were found. U87 cells (Arg/Gly(388)) did not show higher invasion than U138 cells (Gly(388)). This suggests that the FGFR4 codon 388 status does not play a major role in malignant gliomas.

MeSH terms

  • Base Sequence
  • Brain Neoplasms / genetics*
  • Brain Neoplasms / pathology
  • Cell Line, Tumor
  • Codon*
  • DNA Primers
  • Glioma / genetics*
  • Glioma / pathology
  • Humans
  • Immunohistochemistry
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length
  • Polymorphism, Single Nucleotide*
  • Receptor, Fibroblast Growth Factor, Type 4 / genetics*

Substances

  • Codon
  • DNA Primers
  • FGFR4 protein, human
  • Receptor, Fibroblast Growth Factor, Type 4