Construct validity of Hopkins Verbal Learning Test-Revised component process measures in an HIV-1 sample

Arch Clin Neuropsychol. 2005 Dec;20(8):1061-71. doi: 10.1016/j.acn.2005.06.007. Epub 2005 Sep 29.


Executive dyscontrol of episodic verbal learning and memory secondary to prefrontostriatal circuit neuropathophysiology is a common feature of HIV-1 infection. Prior research indicates that standard clinical learning and recall indexes from Hopkins Verbal Learning Test-Revised (HVLT-R) are among the most sensitive indicators of HIV-associated neurocognitive disorders. Emerging data support the validity of qualitative component process measures derived from the HVLT-R (e.g., Semantic Clustering); however, no prior studies have examined these particular indices of performance in an HIV-1-infected population. In the present study, we examined the construct validity of HVLT-R component process indices in a sample of 42 persons with HIV-1 infection and 29 demographically similar seronegative comparison participants. The HIV-1 sample performed significantly below the seronegative group on Total and Delayed Recall, Semantic Clustering, and the Retrieval Index. No between-group differences were observed on Serial Clustering, Pair Frequency, Learning, Repetitions, Semantic False Positive Recognition Errors, or the Recognition Discrimination Index. In addition, the HVLT-R component process measures demonstrated evidence of convergent and divergent validity with standard clinical tests in the HIV-1 sample. Findings support the construct validity of HVLT-R component process measures and are commensurate with prior literature indicating that HIV-1 disease is associated with deficient executive control of encoding and retrieval within verbal episodic memory.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Case-Control Studies
  • Cerebral Cortex / physiopathology
  • Female
  • HIV Infections / physiopathology
  • HIV Infections / psychology*
  • HIV-1*
  • Humans
  • Male
  • Memory / physiology*
  • Middle Aged
  • Neuropsychological Tests*
  • Psychometrics
  • Reproducibility of Results
  • Verbal Learning / physiology*