Int J Biochem Cell Biol. 2006 Feb;38(2):152-6. doi: 10.1016/j.biocel.2005.08.012. Epub 2005 Sep 15.


The members of the Syndecan family of heparan sulfate proteoglycans play diverse roles in cell adhesion and cell communication by serving as co-receptors for both cell-signaling and extracellular matrix molecules. Syndecan-2 has been implicated in the formation of specialized membrane domains and functions as a direct link between the extracellular environment and the organization of the cortical cytoplasm. Recent studies have shown that syndecan-2 is required for angiogenesis, possibly by serving as a co-receptor for vascular endothelial growth factor, and cell-to-cell signaling during development of left-right asymmetry. This unique combination of activities suggests that syndecan-2 can function as a potential drug target for the development of multi-functional, anti-cancer therapeutics.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Adhesion / physiology
  • Cell Communication / physiology
  • Extracellular Matrix / metabolism
  • Humans
  • Membrane Glycoproteins* / chemistry
  • Membrane Glycoproteins* / genetics
  • Membrane Glycoproteins* / metabolism
  • Protein Structure, Tertiary
  • Proteoglycans* / chemistry
  • Proteoglycans* / genetics
  • Proteoglycans* / metabolism
  • Signal Transduction / physiology
  • Syndecan-2


  • Membrane Glycoproteins
  • Proteoglycans
  • SDC2 protein, human
  • Syndecan-2