Mitochondria: pharmacological manipulation of cell death

J Clin Invest. 2005 Oct;115(10):2640-7. doi: 10.1172/JCI26274.


Cell death by apoptosis or necrosis is often important in the etiology and treatment of disease. Since mitochondria play important roles in cell death pathways, these organelles are potentially prime targets for therapeutic intervention. Here we discuss the mechanisms through which mitochondria participate in the cell death process and also survey some of the pharmacological approaches that target mitochondria in various ways.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Apoptosis / physiology*
  • Cell Membrane Permeability / drug effects
  • Cell Membrane Permeability / physiology
  • Drug Design
  • Humans
  • Mitochondria / drug effects
  • Mitochondria / metabolism*
  • Pharmaceutical Preparations / metabolism
  • Signal Transduction / drug effects
  • Signal Transduction / physiology*


  • Pharmaceutical Preparations