Caspases: pharmacological manipulation of cell death

J Clin Invest. 2005 Oct;115(10):2665-72. doi: 10.1172/JCI26252.

Abstract

Caspases, a family of cysteine proteases, play a central role in apoptosis. During the last decade, major progress has been made to further understand caspase structure and function, providing a unique basis for drug design. This Review gives an overview of caspases and their classification, structure, and substrate specificity. We also describe the current knowledge of how interference with caspase signaling can be used to pharmacologically manipulate cell death.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Apoptosis / physiology*
  • Caspase Inhibitors
  • Caspases / chemistry
  • Caspases / classification
  • Caspases / metabolism*
  • Drug Delivery Systems / methods
  • Drug Design
  • Humans
  • Protease Inhibitors / chemistry
  • Protease Inhibitors / metabolism
  • Protease Inhibitors / pharmacology
  • Protein Structure, Tertiary
  • Signal Transduction / drug effects
  • Signal Transduction / physiology*
  • Structure-Activity Relationship
  • Substrate Specificity / physiology

Substances

  • Caspase Inhibitors
  • Protease Inhibitors
  • Caspases