Moonlighting vacuolar protease: multiple jobs for a busy protein

Trends Plant Sci. 2005 Nov;10(11):516-8. doi: 10.1016/j.tplants.2005.09.002. Epub 2005 Oct 3.


In this Genomics Era with a wealth of annotated sequence data, it is easy to pigeonhole a protein into a particular function. However, Noa Matarasso et al. recently found a vacuolar protease that can also function as a transcription factor. This work illustrates that a protein can serve multiple roles in a cell, raising intriguing questions as to the extent that genomic information can be deciphered de novo.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Ethylenes / biosynthesis
  • Peptide Hydrolases / metabolism*
  • Plant Proteins / genetics
  • Plant Proteins / physiology
  • Transcription Factors / metabolism
  • Vacuoles / enzymology*


  • Ethylenes
  • Plant Proteins
  • Transcription Factors
  • ethylene
  • Peptide Hydrolases