BK virus regulatory region sequence deletions in a case of human polyomavirus associated nephropathy (PVAN) after kidney transplantation

J Clin Virol. 2006 Jan;35(1):106-8. doi: 10.1016/j.jcv.2005.08.003. Epub 2005 Sep 30.


The pathogenesis of polyomavirus-associated interstitial nephropathy (PVAN) in kidney transplant recipients is likely to depend upon multiple risk factors, which may include viral characteristics. We report a case of interstitial nephropathy in a young kidney allograft recipient, associated with a BK virus (BKV) strain with a rearranged transcription control region (TCR). BKV strains with deletions and nucleotide substitutions in the TCR were present in a kidney biopsy and urine samples. After retransplantation, following loss of renal function, a BKV strain with an archetypal TCR was detected in association with asymptomatic reactivation.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • BK Virus / genetics
  • Humans
  • Kidney Transplantation / adverse effects*
  • Male
  • Nephritis, Interstitial / virology*
  • Polyomavirus Infections / virology*
  • Regulatory Sequences, Nucleic Acid
  • Sequence Deletion*
  • Tumor Virus Infections / virology*