Association between bronchial asthma in pregnancy and shorter gestational age in a population-based study

J Matern Fetal Neonatal Med. 2005 Aug;18(2):107-12. doi: 10.1080/14767050500198337.


Objective: To study the association between bronchial asthma during pregnancy and gestational age/birth weight, and also preterm birth and low birth weight.

Method: In the population-based large data set of the Hungarian Case-Control Surveillance System of Congenital Abnormalities, 1980-1996, controls without congenital abnormalities were analysed.

Results: Of 38,151 newborn infants, 757 (2.0%) had mothers with bronchial asthma during pregnancy, 88% were medically recorded prospectively. Mothers with bronchial asthma in pregnancy had 0.6 week shorter gestational age and a higher proportion of preterm births (14.1% vs. 9.1%). These findings were reflected with a lower mean birth weight (3,102 vs. 3,279 gram) and higher proportion of low birth weight newborns (9.0% vs. 5.6%).

Conclusion: The old fashioned anti-asthmatic drugs were not able to prevent the bronchial asthma-related preterm birth, thus there is an urgent need to use modern inhaled therapies.

MeSH terms

  • Adult
  • Anti-Asthmatic Agents / therapeutic use
  • Asthma / epidemiology*
  • Asthma / etiology
  • Asthma / prevention & control
  • Birth Weight
  • Case-Control Studies
  • Female
  • Gestational Age
  • Humans
  • Hungary / epidemiology
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Infant, Premature
  • Male
  • Pregnancy
  • Pregnancy Complications / epidemiology*
  • Pregnancy Complications / etiology
  • Pregnancy Complications / prevention & control
  • Premature Birth
  • Prospective Studies


  • Anti-Asthmatic Agents