Histamine H4 receptor expression in human synovial cells obtained from patients suffering from rheumatoid arthritis

Biol Pharm Bull. 2005 Oct;28(10):2016-8. doi: 10.1248/bpb.28.2016.


While histamine H4 receptor (H4R) has been implicated in immune system disturbances in different organ tissues, the presence and possible roles of H4R in synovial cells (SC) of rheumatoid arthritis (RA) patients has not previously been documented. This study conclusively evidences H4R expression in SC of RA patients by use of RT-PCR method. As RA consists mainly of immunological disturbances in SC of RA patients, this study's findings document a novel histamine action site, and opens potential new avenues to investigate mechanisms and to develop pharmacotherapeutic agents for the disease.

MeSH terms

  • Arthritis, Rheumatoid / metabolism*
  • Arthritis, Rheumatoid / pathology
  • Base Sequence
  • DNA Primers
  • Electrophoresis, Agar Gel
  • Humans
  • RNA, Messenger / genetics
  • Receptors, G-Protein-Coupled / genetics
  • Receptors, G-Protein-Coupled / metabolism*
  • Receptors, Histamine / genetics
  • Receptors, Histamine / metabolism*
  • Receptors, Histamine H4
  • Synovial Membrane / metabolism*
  • Synovial Membrane / pathology


  • DNA Primers
  • HRH4 protein, human
  • RNA, Messenger
  • Receptors, G-Protein-Coupled
  • Receptors, Histamine
  • Receptors, Histamine H4