Plant cannabinoids: a neglected pharmacological treasure trove

Br J Pharmacol. 2005 Dec;146(7):913-5. doi: 10.1038/sj.bjp.0706415.


Most of the cannabinoids in Cannabis sativa L. have not been fully evaluated for their pharmacological activity. A publication in this issue presents evidence that a plant cannabinoid, Delta(9)-tetrahydrocannabivarin is a potent antagonist of anandamide, a major endogenous cannabinoid. It seems possible that many of the non-psychoactive constituents of this plant will be of biological interest.

Publication types

  • Comment

MeSH terms

  • Animals
  • Arachidonic Acids / antagonists & inhibitors
  • Cannabinoids / pharmacology*
  • Cannabis / chemistry*
  • Endocannabinoids
  • Male
  • Mice
  • Polyunsaturated Alkamides
  • Receptor, Cannabinoid, CB1 / antagonists & inhibitors*
  • Receptor, Cannabinoid, CB2 / antagonists & inhibitors*


  • Arachidonic Acids
  • Cannabinoids
  • Endocannabinoids
  • Polyunsaturated Alkamides
  • Receptor, Cannabinoid, CB1
  • Receptor, Cannabinoid, CB2
  • anandamide