Effect of Oral Intake of Choline-Stabilized Orthosilicic Acid on Skin, Nails and Hair in Women With Photodamaged Skin

Arch Dermatol Res. 2005 Oct;297(4):147-53. doi: 10.1007/s00403-005-0584-6. Epub 2005 Oct 26.

Abstract

Chronic exposure of the skin to sunlight causes damage to the underlying connective tissue with a loss of elasticity and firmness. Silicon (Si) was suggested to have an important function in the formation and maintenance of connective tissue. Choline-stabilized orthosilicic acid ("ch-OSA") is a bioavailable form of silicon which was found to increase the hydroxyproline concentration in the dermis of animals. The effect of ch-OSA on skin, nails and hair was investigated in a randomized, double blind, placebo-controlled study. Fifty women with photodamaged facial skin were administered orally during 20 weeks, 10 mg Si/day in the form of ch-OSA pellets (n=25) or a placebo (n=25). Noninvasive methods were used to evaluate skin microrelief (forearm), hydration (forearm) and mechanical anisotropy (forehead). Volunteers evaluated on a virtual analog scale (VAS, "none=0, severe=3") brittleness of hair and nails. The serum Si concentration was significantly higher after a 20-week supplementation in subjects with ch-OSA compared to the placebo group. Skin roughness parameters increased in the placebo group (Rt:+8%; Rm: +11%; Rz: +6%) but decreased in the ch-OSA group (Rt: -16%; Rm: -19%; Rz: -8%). The change in roughness from baseline was significantly different between ch-OSA and placebo groups for Rt and Rm. The difference in longitudinal and lateral shear propagation time increased after 20 weeks in the placebo group but decreased in the ch-OSA group suggesting improvement in isotropy of the skin. VAS scores for nail and hair brittleness were significantly lower after 20 weeks in the ch-OSA group compared to baseline scores. Oral intake of ch-OSA during the 20 weeks results in a significant positive effect on skin surface and skin mechanical properties, and on brittleness of hair and nails.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adult
  • Aged
  • Biomechanical Phenomena
  • Choline*
  • Double-Blind Method
  • Face
  • Female
  • Hair / drug effects*
  • Hair / pathology
  • Hair / physiopathology
  • Humans
  • Hydroxyproline / metabolism
  • Middle Aged
  • Nails / drug effects*
  • Nails / pathology
  • Nails / physiopathology
  • Silicic Acid / administration & dosage*
  • Silicic Acid / pharmacology
  • Silicic Acid / therapeutic use
  • Silicon / blood
  • Skin / drug effects*
  • Skin / metabolism
  • Skin / pathology
  • Skin / radiation effects*
  • Time Factors
  • Ultraviolet Rays / adverse effects*

Substances

  • Silicic Acid
  • Choline
  • Hydroxyproline
  • Silicon