Between 1998 and 2004 1341 Red Foxes from 611 locations were examined parasitologically for Echinococcus multilocularis at the State Office of Consumer Protection Saxony-Anhalt. Examination was carried out in parallel to rabies monitoring. A period-prevalence of 9.2% of infestation was found. Employing a Scan Statistic a large area in the southwest of the federal state and two smaller areas of increased risk with respect to infestation with Echinococcus multilocularis were identified. The hypothesis of a negative association of the probability of infestation with the average annual maximum temperature of the location where the foxes were shot was supported by logistic regression analysis. A decreased probability of inactivation of Echinococcus multilocularis-oncospheres through heat and desiccation in areas of lower average annual maximum temperature seems to be likely.Thus, the infection pressure increases with reduced temperatures.