Clinical and laboratory characteristics of drug-induced vasculitic syndromes

Arthritis Res Ther. 2005;7(5):191-2. doi: 10.1186/ar1805. Epub 2005 Aug 24.

Abstract

Clinical recognition of drug-induced vasculitic and lupus-like syndromes is very important because continued use of the offending drug can lead to irreversible and life-threatening vasculitic organ damage (e.g. end-stage renal disease or pulmonary haemorrhage). Withdrawal of the drug often leads to spontaneous recovery, meaning that immunosuppressive therapy can be avoided. The presence of myeloperoxidase-antineutrophil cytoplasmic antibodies, IgM anticardiolipin antibody, and antihistone antibodies in combination was found to be characteristic of drug-induced vasculitic syndromes caused by the antithyroid drugs propylthiouracil and methimazol. Clinically, skin vasculitis and arthralgias predominated and renal vasculitis was rare.

Publication types

  • Comment

MeSH terms

  • Acute Kidney Injury / etiology
  • Antibodies, Anticardiolipin / blood
  • Antibodies, Antineutrophil Cytoplasmic / blood
  • Antithyroid Agents / adverse effects
  • Autoantibodies / blood*
  • Autoimmune Diseases / blood
  • Autoimmune Diseases / chemically induced*
  • Autoimmune Diseases / complications
  • Autoimmune Diseases / diagnosis
  • Autoimmune Diseases / immunology
  • Churg-Strauss Syndrome / diagnosis
  • Diagnosis, Differential
  • Granulomatosis with Polyangiitis / diagnosis
  • Humans
  • Immunoglobulin M / blood
  • Kidney / blood supply
  • Lupus Erythematosus, Systemic / chemically induced
  • Lupus Erythematosus, Systemic / diagnosis
  • Methimazole / adverse effects
  • Propylthiouracil / adverse effects
  • Skin / blood supply
  • Thrombophilia / etiology
  • Vasculitis, Leukocytoclastic, Cutaneous / blood
  • Vasculitis, Leukocytoclastic, Cutaneous / chemically induced*
  • Vasculitis, Leukocytoclastic, Cutaneous / complications
  • Vasculitis, Leukocytoclastic, Cutaneous / diagnosis
  • Vasculitis, Leukocytoclastic, Cutaneous / immunology

Substances

  • Antibodies, Anticardiolipin
  • Antibodies, Antineutrophil Cytoplasmic
  • Antithyroid Agents
  • Autoantibodies
  • Immunoglobulin M
  • Methimazole
  • Propylthiouracil