Combined Merkel cell carcinoma and atypical fibroxanthoma

J Cutan Med Surg. 2005 Jan;9(1):6-9. doi: 10.1007/s10227-005-0024-4.


Background: Although there are reports of squamous cell carcinoma arising within and adjacent to Merkel cell carcinoma, and one report of an atypical fibroxanthoma-like tumor arising in an irradiated recurrent Merkel cell carcinoma, there have previously been no reports of an immunohistochemically verified atypical fibroxanthoma occurring in conjunction with a Merkel cell carcinoma.

Objective: We report on a neoplasm with distinct features of both Merkel cell carcinoma and atypical fibroxanthoma.

Methods: Histologic and immunohistochemical evaluations were performed.

Results: Our results verify the finding of a combined Merkel cell carcinoma and atypical fibroxanthoma.

Conclusion: This case is an interesting and unusual combination of tumors. The origin of the Merkel cell carcinoma is revisited. Debated origins include neuroendocrine, epithelial, and pleuripotent stem cell.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Carcinoma, Merkel Cell / diagnosis*
  • Carcinoma, Merkel Cell / therapy
  • Diagnosis, Differential
  • Fatal Outcome
  • Histiocytoma, Malignant Fibrous / diagnosis*
  • Histiocytoma, Malignant Fibrous / therapy
  • Humans
  • Immunohistochemistry
  • Lip Neoplasms / diagnosis*
  • Lip Neoplasms / therapy
  • Male