Treatment of severe, recalcitrant, major aphthous stomatitis with adalimumab

Cutis. 2005 Aug;76(2):129-32.


We describe an 18-year-old man with a 7-year history of severe major aphthous stomatitis refractory to multiple standard therapies who responded completely to therapy with adalimumab, a fully humanized monoclonal antibody against tumor necrosis factor alpha (TNF-alpha).

Publication types

  • Case Reports

MeSH terms

  • Adalimumab
  • Adolescent
  • Antibodies, Monoclonal / therapeutic use*
  • Antibodies, Monoclonal, Humanized
  • Humans
  • Male
  • Recurrence
  • Stomatitis, Aphthous / drug therapy*
  • Tumor Necrosis Factor-alpha / immunology


  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Tumor Necrosis Factor-alpha
  • Adalimumab