Sp transcription factor family and its role in cancer

Eur J Cancer. 2005 Nov;41(16):2438-48. doi: 10.1016/j.ejca.2005.08.006. Epub 2005 Oct 4.


Specificity protein 1 (Sp1) and other Sp and Krüppel-like factor (KLF) proteins are members of a family of transcription factors which bind GC/GT-rich promoter elements through three C(2)H(2)-type zinc fingers that are present at their C-terminal domains. Sp1-Sp4 proteins regulate expression of multiple genes in normal tissues and tumours. There is growing evidence that some Sp proteins play a critical role in the growth and metastasis of many tumour types by regulating expression of cell cycle genes and vascular endothelial growth factor. Sp/KLF proteins are also potential targets for cancer chemotherapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Cell Survival
  • Gene Expression
  • Humans
  • Neoplasms / genetics*
  • Sp Transcription Factors / classification
  • Sp Transcription Factors / genetics*
  • Sp Transcription Factors / physiology
  • Vascular Endothelial Growth Factor A / genetics


  • Sp Transcription Factors
  • Vascular Endothelial Growth Factor A