The role of collagen in bone structure: an image processing approach

Micron. 2005;36(7-8):593-601. doi: 10.1016/j.micron.2005.05.009. Epub 2005 Sep 1.

Abstract

Bone collagen structure in normal and pathological tissues is illustrated using techniques of thin section transmission electron microscopy and computer-assisted analysis. The normal bone collagen types, fibril architecture and diameter are described. In pathological tissue, deviations from normal fine structure are reflected in abnormal arrangements of collagen fibrils and abnormalities in fibril diameter. Computer analyses of normal fibril positive staining patterns are presented in order to provide a basis for comparing such patterns with pathological ones.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Diseases / pathology
  • Bone Diseases / physiopathology
  • Bone and Bones / chemistry
  • Bone and Bones / physiology
  • Bone and Bones / ultrastructure*
  • Collagen / analysis
  • Collagen / physiology*
  • Collagen / ultrastructure*
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Microscopy, Electron, Transmission
  • Osteoporosis / pathology
  • Osteoporosis / physiopathology
  • Tibia / chemistry
  • Tibia / physiology
  • Tibia / ultrastructure

Substances

  • Collagen