Critical investigation of the CD14 promoter polymorphism: lack of a role for in vitro cytokine response and membrane CD14 expression

Clin Diagn Lab Immunol. 2005 Oct;12(10):1254-6. doi: 10.1128/CDLI.12.10.1254-1256.2005.

Abstract

Blood of volunteers, genotyped for the CD14 C(-159)-->T polymorphism, showed no difference in cytokine release when stimulated with nine CD14-dependent immune stimuli. An analysis of the published data on the proposed association of CD14 genotype with membrane CD14 density revealed no significant correlation, questioning a functional impact of the CD14 polymorphism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cells, Cultured
  • Cytokines / biosynthesis
  • Gene Expression Regulation / genetics
  • Genotype
  • Humans
  • Immunity
  • Lipopolysaccharide Receptors / genetics*
  • Lipopolysaccharides / pharmacology
  • Monocytes / immunology
  • Polymorphism, Single Nucleotide / immunology*
  • Promoter Regions, Genetic / genetics*

Substances

  • Cytokines
  • Lipopolysaccharide Receptors
  • Lipopolysaccharides