Protein production and crystallization at the joint center for structural genomics

J Struct Funct Genomics. 2005;6(2-3):71-9. doi: 10.1007/s10969-005-2897-2.


By definition, structural genomics centers must be able to address a large number of diverse protein targets. The methods developed should permit parallel and cost-effective processing while allowing for the diverse nature of proteins. Our approach to this problem is a multi-tiered effort where targets are characterized and categorized by behavior and processed in parallel by appropriate methods. The Joint Center for Structural Genomics (JCSG) has applied this tactic to create a fully integrated and scaleable structure determination pipeline. Highlights of the development of the current pipeline for protein production and crystallization are presented here.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Crystallization / methods*
  • Databases, Protein*
  • Models, Molecular*
  • Proteins / chemistry*
  • Proteins / isolation & purification*
  • Proteomics / methods*


  • Proteins