Leptomeningeal metastasis of primary central nervous system (CNS) neoplasms

Cancer Treat Res. 2005;125:71-85. doi: 10.1007/0-387-24199-x_5.


Leptomeningeal dissemination of primary CNS tumors varies widely by histologic subtype. In certain tumors including medulloblastoma, ependymoma, germ cell tumors, and primary CNS lymphoma, seeding of the cerebrospinal fluid space is a critical factor in determining stage, prognosis and appropriate therapy. Other tumor types, such as glioma, may have radiographic evidence of leptomeningeal metastases without clear impact on prognosis or therapy.

Publication types

  • Review

MeSH terms

  • Adult
  • Brain Neoplasms / classification
  • Brain Neoplasms / pathology*
  • Central Nervous System Neoplasms / classification
  • Central Nervous System Neoplasms / pathology*
  • Child
  • Humans
  • Incidence
  • Meningeal Neoplasms / epidemiology
  • Meningeal Neoplasms / secondary*