Expression of tcaA and mprF and Glycopeptide Resistance in Clinical Glycopeptide-Intermediate Staphylococcus Aureus (GISA) and heteroGISA Strains

Biochim Biophys Acta. 2005 Nov 30;1726(3):326-7. doi: 10.1016/j.bbagen.2005.09.002. Epub 2005 Sep 22.

Abstract

Two genes recently associated with glycopeptide intermediate resistance in Staphylococcus aureus (GISA) are mprF and tcaA, with inactivation causing shifts in vancomycin resistance. This study reveals that expression levels of both genes are similar in groups of clinical GISA, heteroGISA and glycopeptide susceptible strains, suggesting no association with clinical isolates.

MeSH terms

  • Aminoacyltransferases
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Gene Expression
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / isolation & purification
  • Staphylococcus aureus / metabolism
  • Vancomycin Resistance*

Substances

  • Bacterial Proteins
  • Aminoacyltransferases
  • mprF protein, Staphylococcus aureus