Structure-function studies of DNA polymerase lambda

DNA Repair (Amst). 2005 Dec 8;4(12):1358-67. doi: 10.1016/j.dnarep.2005.09.001. Epub 2005 Oct 4.


DNA polymerase lambda is a member of the X family of polymerases that is implicated in non-homologous end-joining of double-strand breaks in DNA and in base excision repair of DNA damage. To better understand the roles of DNA polymerase lambda in these repair pathways, here we review its structure and biochemical properties, with emphasis on its gap-filling polymerization activity, its dRP lyase activity and its unusual DNA synthetic (in)fidelity.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • DNA Polymerase beta / chemistry*
  • DNA Polymerase beta / classification
  • DNA Polymerase beta / metabolism*
  • Humans
  • Nucleic Acid Conformation
  • Phosphorus-Oxygen Lyases / chemistry
  • Phosphorus-Oxygen Lyases / metabolism
  • Protein Structure, Tertiary
  • Structure-Activity Relationship


  • 5'-deoxyribose phosphate lyase
  • DNA polymerase beta2
  • DNA Polymerase beta
  • Phosphorus-Oxygen Lyases