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Review
. 2005 Oct 7;123(1):9-12.
doi: 10.1016/j.cell.2005.09.017.

The Blood-Brain Barrier--Lessons From Moody Flies

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Review

The Blood-Brain Barrier--Lessons From Moody Flies

Richard Daneman et al. Cell. .

Abstract

Despite the importance of the blood-brain barrier (BBB), little is known about the molecular mechanisms that control its integrity. The identification of moody, a gene required for the formation and maintenance of the Drosophila BBB, provides new insight into how paracellular junctions are formed at the barrier. Meanwhile, moody also has been identified in a screen for fly mutants with altered sensitivity to cocaine, remarkably implicating the BBB in the physiological response to narcotics.

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