Outcome of renal transplantation in children with low urinary tract abnormality

Transplant Proc. 2005 Sep;37(7):3071-4. doi: 10.1016/j.transproceed.2005.08.026.


Introduction: Patients with end-stage renal disease and lower urinary tract abnormality are often considered high risk for renal transplantation.

Methods and subjects: To examine the degree of risk, we studied patients who received renal transplants between 1985 and 2003. Forty eight patients had congenital lower urinary tract anomalies and 168 patients comprised a control group without these anomalies.

Results: Mean age and distribution of sex were not significantly different between the case and the control group. Among patients with anomalies, 8% had delayed graft function; 75%, acute rejection; and 39.5%, chronic rejection. Among the controls 2.3% had delayed graft function; 59%, acute rejection; and 35%, chronic rejection. None of these differences was significant. Mean survival time was 6 years in affected patients and 7.3 years in the control group (P = .7). Among patients with anomalies the rate of graft survival in the first year after transplantation was 90%; and those in the third, fifth, and seventh years, 76%, 65%, and 40%, respectively. For the controls, the graft survivals were 88% at 1 year; 73% at 3 years; 70% at 5 years; and 49% at 7 years after transplantation.

Conclusion: This study showed that a history of lower urinary tract anomalies had no effect on graft function. Graft survival was not different among these patients compared with patients free of these anomalies.

Publication types

  • Comparative Study

MeSH terms

  • Acute Disease
  • Child
  • Chronic Disease
  • Creatinine / blood
  • Female
  • Graft Rejection / epidemiology
  • Graft Survival
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Kidney Transplantation / immunology
  • Kidney Transplantation / physiology*
  • Male
  • Retrospective Studies
  • Treatment Outcome
  • Urinary Tract / abnormalities*


  • Immunosuppressive Agents
  • Creatinine