Critically short telomeres are associated with sperm DNA fragmentation

Fertil Steril. 2005 Oct;84(4):843-5. doi: 10.1016/j.fertnstert.2005.05.014.

Abstract

The influence of critical telomeric attrition, a well-known trigger of apoptosis and cell arrest, on sperm DNA fragmentation was studied in late-generation knockout mice for Terc, the RNA component of telomerase, as a model of choice. Terc knockout mice had a sixfold mean increase in the percentage of sperm cells with fragmented DNA.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • DNA Fragmentation / genetics*
  • Genetic Techniques
  • In Situ Hybridization, Fluorescence / methods
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Spermatozoa / pathology
  • Spermatozoa / physiology*
  • Telomere / genetics*
  • Telomere / pathology