In vitro oocyte maturation and subsequent delayed fertilization is associated with increased embryo aneuploidy

Benjamin R Emery; Aaron L Wilcox; Vincent W Aoki; C Matthew Peterson; Douglas T Carrell

doi:10.1016/j.fertnstert.2005.04.036

In vitro oocyte maturation and subsequent delayed fertilization is associated with increased embryo aneuploidy

Fertil Steril. 2005 Oct;84(4):1027-9. doi: 10.1016/j.fertnstert.2005.04.036.

Authors

Benjamin R Emery¹, Aaron L Wilcox, Vincent W Aoki, C Matthew Peterson, Douglas T Carrell

Affiliation

¹ Division of Urology, Department of Surgery, Utah School of Medicine, Salt Lake City, Utah, USA.

PMID: 16213866
DOI: 10.1016/j.fertnstert.2005.04.036

Abstract

Failed fertilization and the appearance of immature oocytes are common in IVF practice; rescue intracytoplasmic sperm injection can be used as a therapy. However, this study indicates that embryos created after in vitro maturation and delayed intracytoplasmic sperm injection contain an increase in aneuploidy (79.7%) over control embryos (60.5%). Therefore, patients should be informed of the possible risk when presented with delayed intracytoplasmic sperm injection.

Publication types

Comparative Study

MeSH terms

Adult
Aneuploidy*
Chi-Square Distribution
Embryo, Mammalian / physiology*
Female
Fertilization / genetics*
Humans
Oocytes / growth & development
Oocytes / physiology*
Sperm Injections, Intracytoplasmic / methods*
Time Factors