Hydrolysed milk in preterm infants: an open problem

Acta Paediatr Suppl. 2005 Oct;94(449):84-6. doi: 10.1111/j.1651-2227.2005.tb02160.x.


Aim: To review knowledge about the role, indications and nutritional adequacy of protein hydrolysate formulas (HF) in the preterm newborn.

Methods: A review of the available literature was carried out.

Results: No data support the use of HF for atopy prevention. HF could have a positive role in the early feeding of very-low-birthweight infants, but several concerns exist about their nutritional adequacy.

Conclusion: Further investigations addressing protein and mineral metabolism as well as long-term effects, including neurodevelopment, are needed.

Publication types

  • Review

MeSH terms

  • Child Development / physiology
  • Humans
  • Hydrolysis
  • Infant Nutritional Physiological Phenomena / physiology*
  • Infant, Newborn
  • Infant, Premature
  • Milk Hypersensitivity / prevention & control*
  • Milk, Human / chemistry*
  • Nutritional Requirements
  • Nutritional Support
  • Protein Hydrolysates / chemistry*


  • Protein Hydrolysates