Neurotrophic keratopathy and diabetes mellitus

Eye (Lond). 2006 Jul;20(7):837-9. doi: 10.1038/sj.eye.6702053. Epub 2005 Oct 7.


Diabetes mellitus is frequently associated with microvascular complications such as retinopathy, nephropathy, and peripheral neuropathy. Neurotrophic keratopathy occurs in response to a neuropathy of the ophthalmic division of the trigeminal nerve. Rarely has diabetic neurotrophic keratopathy been described. This paper discusses the ophthalmic histories of three patients who presented with diabetic neurotrophic keratopathy. In one patient the corneal ulceration was the sole presenting feature of his diabetes. We discuss the need for increased vigilance in the ophthalmic community for suspecting diabetes in patients with unexplained corneal epithelial disease.

Publication types

  • Case Reports

MeSH terms

  • Administration, Topical
  • Adult
  • Cornea / innervation*
  • Cornea / pathology
  • Corneal Ulcer / diagnosis*
  • Corneal Ulcer / drug therapy
  • Diabetes Mellitus, Type 1 / diagnosis*
  • Female
  • Follow-Up Studies
  • Glucocorticoids / administration & dosage
  • Humans
  • Male
  • Trigeminal Nerve Diseases / diagnosis*
  • Trigeminal Nerve Diseases / drug therapy


  • Glucocorticoids