Treatment approaches to symptoms associated with frontotemporal degeneration

Curr Psychiatry Rep. 2005 Oct;7(5):376-80. doi: 10.1007/s11920-005-0040-5.


A systematic review of the literature reveals few randomized, controlled trials for drug therapy in frontotemporal degeneration (FTD). Although there is evidence to support a serotonergic deficit, and clinicians frequently prescribe selective serotonin reuptake inhibitors to patients with FTD, only paroxetine and trazodone have been studied. There is Class II evidence for use of rivastigmine in FTD behavioral disturbances, although there is no consistent evidence of cholinergic deficit in this illness.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Aphasia / drug therapy
  • Aphasia / etiology
  • Caregivers / psychology
  • Clinical Trials as Topic
  • Cognition Disorders / drug therapy*
  • Cognition Disorders / etiology*
  • Dementia / complications*
  • Dopamine Agents / therapeutic use
  • Humans
  • Memantine / therapeutic use
  • Selective Serotonin Reuptake Inhibitors / therapeutic use*


  • Dopamine Agents
  • Serotonin Uptake Inhibitors
  • Memantine