Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation

FEBS J. 2005 Oct;272(20):5169-81. doi: 10.1111/j.1742-4658.2005.04939.x.


The abundance and size of cellular organelles vary depending on the cell type and metabolic needs. Peroxisomes constitute a class of cellular organelles renowned for their ability to adapt to cellular and environmental conditions. Together with transcriptional regulators, two groups of peroxisomal proteins have a pronounced influence on peroxisome size and abundance. Pex11-type peroxisome proliferators are involved in the proliferation of peroxisomes, defined here as an increase in size and/or number of peroxisomes. Dynamin-related proteins have recently been suggested to be required for the scission of peroxisomal membranes. This review surveys the function of Pex11-type peroxisome proliferators and dynamin-related proteins in peroxisomal proliferation and division.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carrier Proteins
  • Dynamins / physiology*
  • Endocytosis / physiology
  • GTP Phosphohydrolases / physiology
  • GTP-Binding Proteins / physiology
  • Humans
  • Membrane Proteins / physiology
  • Microtubule-Associated Proteins / physiology
  • Mitochondria / physiology
  • Mitochondrial Proteins / physiology
  • Models, Biological
  • Myxovirus Resistance Proteins
  • Perilipin-1
  • Peroxins
  • Peroxisomes / physiology*
  • Phosphoproteins / physiology
  • Protein Isoforms / physiology
  • Saccharomyces cerevisiae Proteins / physiology
  • Vesicular Transport Proteins


  • Carrier Proteins
  • Membrane Proteins
  • Microtubule-Associated Proteins
  • Mitochondrial Proteins
  • Myxovirus Resistance Proteins
  • PEX11 protein, S cerevisiae
  • Perilipin-1
  • Peroxins
  • Phosphoproteins
  • Protein Isoforms
  • Saccharomyces cerevisiae Proteins
  • Vesicular Transport Proteins
  • GTP Phosphohydrolases
  • GTP-Binding Proteins
  • VPS1 protein, S cerevisiae
  • DNM1L protein, human
  • Dynamins