It is estimated that between 1,500 and 2,000 Danish doctors are using acupuncture in their daily practice, in particular for diseases in the locomotor system. The purpose of this paper is to clarify what acupuncture's possible mode of action is and for which diseases within the locomotor system acceptable evidence exists for its use. The author concludes that reasonable scientific evidence exists for the alleviation of myogenic facial pain, neck pain, shoulder pain, elbow pain, low back pain and knee pain. Moreover, the author points out that acupuncture is a very safe technique in the hands of a qualified doctor with special training in the discipline.