Viral shedding in children with influenza virus infections treated with neuraminidase inhibitors

Pediatr Infect Dis J. 2005 Oct;24(10):931-2. doi: 10.1097/01.inf.0000180976.81055.ce.

Abstract

We examined the efficacy of neuraminidase inhibitors for reducing the duration of virus shedding after naturally occurring influenza virus infection. The duration of fever was significantly shorter in patients treated with neuraminidase inhibitors than in untreated patients. The durations of virus shedding from patients treated with neuraminidase inhibitors were not significantly shorter than those of untreated patients.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Acetamides / therapeutic use*
  • Animals
  • Antiviral Agents / administration & dosage
  • Antiviral Agents / therapeutic use*
  • Cell Line
  • Child
  • Child, Preschool
  • Chlorocebus aethiops
  • Guanidines / therapeutic use*
  • Humans
  • Infant
  • Influenza A Virus, H3N2 Subtype / isolation & purification
  • Influenza B virus / isolation & purification
  • Influenza, Human / drug therapy*
  • Influenza, Human / virology
  • Neuraminidase / antagonists & inhibitors*
  • Oseltamivir
  • Pyrans / therapeutic use*
  • Sialic Acids / therapeutic use*
  • Treatment Outcome
  • Vero Cells
  • Virus Shedding*
  • Zanamivir

Substances

  • Acetamides
  • Antiviral Agents
  • Guanidines
  • Pyrans
  • Sialic Acids
  • Oseltamivir
  • Neuraminidase
  • Zanamivir