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Review
, 4 (5), 711-23

Memory Cytolytic T-lymphocytes: Induction, Regulation and Implications for Vaccine Design

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Review

Memory Cytolytic T-lymphocytes: Induction, Regulation and Implications for Vaccine Design

Adriana Baz et al. Expert Rev Vaccines.

Abstract

The design of vaccines that protect against intracellular infections or cancer remains a challenge. In many cases, immunity depends on the development of antigen-specific memory CD8+ T-cells that can express cytokines and kill antigen-bearing cells when they encounter the pathogen or tumor. Here, the authors review current understanding of the signals and cells that lead to memory CD8+ T-cell differentiation, the relationship between the primary CD8+ T-cell response and the memory response and the regulation of memory CD8+ T-cell survival and function. The implications of this new knowledge for vaccine design are discussed, and recent progress in the development of lipidated peptide vaccines as a promising approach for vaccination against intracellular infections and cancer is reviewed.

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