Infective endocarditis complicating rituximab (anti-CD20 monoclonal antibody) treatment in an SLE patient with a past history of Libman-Sacks endocarditis: a case for antibiotic prophylaxis?

Clin Rheumatol. 2006 Jul;25(4):583-4. doi: 10.1007/s10067-005-0031-2. Epub 2005 Oct 13.

Abstract

We report a 54 year old female whose successful treatment of cerebral lupus with rituximab was complicated by the development of streptococcus intermedius, on valves damaged by Libman-Sacks endocarditis more than 20 years previously.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Antibiotic Prophylaxis
  • Antibodies, Monoclonal / adverse effects
  • Antibodies, Monoclonal / therapeutic use*
  • Antibodies, Monoclonal, Murine-Derived
  • Antirheumatic Agents / adverse effects
  • Antirheumatic Agents / therapeutic use*
  • Cefotaxime / therapeutic use
  • Endocarditis, Bacterial / drug therapy*
  • Female
  • Humans
  • Lupus Erythematosus, Systemic / complications*
  • Lupus Erythematosus, Systemic / drug therapy*
  • Lupus Erythematosus, Systemic / physiopathology
  • Middle Aged
  • Penicillin G / therapeutic use
  • Rituximab
  • Streptococcal Infections / complications*
  • Streptococcal Infections / drug therapy
  • Streptococcus intermedius / isolation & purification

Substances

  • Anti-Bacterial Agents
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Murine-Derived
  • Antirheumatic Agents
  • Rituximab
  • Cefotaxime
  • Penicillin G