KL-6 mucin expression in carcinoma of the ampulla of Vater: association with cancer progression

World J Gastroenterol. 2005 Sep 21;11(35):5450-4. doi: 10.3748/wjg.v11.i35.5450.

Abstract

Aim: To assess histochemical expression of KL-6 and its clinicopathological significance in carcinoma of the ampulla of Vater.

Methods: Ampullary carcinoma tissues were collected from 38 patients who underwent pancreatoduodenectomy or local resection. Tissues were subjected to immunohistochemical analysis using KL-6 antibody.

Results: Positive staining of ampullary carcinoma cells was observed in 26 (68.4%) cases. Staining was not found in the surrounding non-cancer regions of the ampullary tissues. Remarkable KL-6 expression was observed in invasive carcinoma cells in pancreatic and duodenal tissues and in metastatic carcinoma cells in lymph nodes. Positive KL-6 expression was related to lymph node metastasis (P = 0.020), pancreatic invasion (P = 0.016), duodenal invasion (P = 0.034), and advanced stage of TNM clinical classification (P = 0.010). Survival analysis showed that positive expression of KL-6 was related to a poorer prognosis (P = 0.029).

Conclusion: The aberrant expression of KL-6 mucin is significantly related to unfavorable behaviors of carcinoma of the ampulla of Vater.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Ampulla of Vater*
  • Antigens / metabolism*
  • Antigens, Neoplasm
  • Common Bile Duct Neoplasms / metabolism*
  • Common Bile Duct Neoplasms / pathology
  • Common Bile Duct Neoplasms / secondary
  • Female
  • Glycoproteins / metabolism*
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Mucin-1
  • Mucins / metabolism*

Substances

  • Antigens
  • Antigens, Neoplasm
  • Glycoproteins
  • MUC1 protein, human
  • Mucin-1
  • Mucins